No drug can exert therapeutic activity if it contains biologically active molecules that cannot cross the biological barriers separating the administration site from the site of action. Many molecules are ineffective because they do not diffuse spontaneously into the cell where the therapeutic target is located in the cell.
Peptides have been used for many years in the field of biotechnology. They have many advantages over small-molecule conventional drugs, but their pharmaceutical use is limited by their low ability to cross membranes, their short half-life and the difficulty to understand their mechanisms of action.
Protein activity regulatory peptides, antimicrobial peptides (AMPs) and peptides blocking protein-protein interactions are promising options for therapeutic use.
BioCellChallenge develops systems that allow peptides to cross membranes in living cells. Thanks to its versatile expertise and its team’s experience in the formulation of lipid systems to transport protein, BCC has developed a proven methodology to support your peptide’s characteristics and optimise membrane transfer.
BCC provides study services to assess and measure the internalisation of your peptide.